MOTS-C - 10mg

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a mitochondrial-derived peptide (MDP) composed of 16 amino acids, discovered as part of the emerging field of mitochondrial signaling molecules. Unlike most peptides encoded by nuclear DNA, MOTS-c is encoded within mitochondrial DNA and functions as a key regulator of cellular metabolism, energy balance, and stress adaptation. It has been extensively studied for its potential to enhance insulin sensitivity, promote fat metabolism, and improve exercise performance—though it is not approved for therapeutic human use.

What Are the Effects of MOTS-c?

• Metabolic Regulation & Insulin Sensitivity: MOTS-c activates the AMPK pathway (AMP-activated protein kinase), a master regulator of cellular energy homeostasis. Research shows it enhances glucose uptake, improves insulin sensitivity, and supports balanced blood sugar levels in metabolic models.
• Fat Utilization & Weight Management: By shifting cells toward oxidative metabolism, MOTS-c promotes fat burning and reduces lipid accumulation, supporting improved body composition and energy efficiency.
• Exercise Performance & Endurance: Preclinical studies demonstrate that MOTS-c increases skeletal muscle adaptation, mitochondrial biogenesis, and endurance capacity, allowing for greater physical performance under stress conditions.
• Cellular Stress Resistance: MOTS-c helps cells adapt to metabolic and oxidative stress by regulating antioxidant gene expression and promoting cellular survival pathways.
• Anti-Aging & Longevity Research: Emerging evidence suggests MOTS-c levels decline with age; supplementation in animal studies has been shown to improve metabolic resilience, reduce inflammation, and extend healthspan.
• Cognitive & Neuroprotective Support: Early research indicates MOTS-c may protect neurons from metabolic and oxidative damage, supporting brain energy metabolism and cognitive stability.
• Safety Observations: MOTS-c has shown high tolerability in animal and early human studies, with no reported adverse systemic effects. Its naturally occurring presence in human tissues supports its ongoing exploration in longevity and metabolic health research.