NAD+ 500mg

What is NAD⁺?

Nicotinamide Adenine Dinucleotide (NAD⁺) is a vital coenzyme present in every cell of the body, playing a central role in energy production, DNA repair, and cellular communication. It acts as a key electron carrier in redox reactions, driving the conversion of nutrients into cellular energy (ATP) within mitochondria. NAD⁺ levels naturally decline with age, oxidative stress, and metabolic dysfunction—prompting extensive research into its role in aging, neuroprotection, and metabolic health. While NAD⁺ is not classified as a therapeutic agent, it remains a cornerstone molecule in longevity and cellular repair research.

What Are the Effects of NAD⁺?

• Cellular Energy & Mitochondrial Function: NAD⁺ is essential for ATP generation through oxidative phosphorylation, supporting optimal cellular metabolism and energy efficiency.
• DNA Repair & Longevity Pathways: NAD⁺ activates sirtuins (SIRT1–SIRT7) and PARP enzymes, which regulate DNA repair, genomic stability, and anti-aging pathways in preclinical research.
• Neuroprotection & Cognitive Support: Studies indicate NAD⁺ may enhance neuronal resilience, improve cognitive performance, and protect against neurodegenerative stressors by stabilizing mitochondrial function and reducing oxidative damage.
• Metabolic Health & Insulin Sensitivity: Increasing NAD⁺ availability has been linked to improved glucose tolerance, lipid metabolism, and insulin sensitivity in laboratory models of metabolic syndrome and obesity.
• Inflammation & Oxidative Stress Reduction: NAD⁺ modulates inflammatory signaling and helps neutralize reactive oxygen species (ROS), supporting overall cellular resilience and recovery from stress or injury.
• Circadian Rhythm & Sleep Regulation: By influencing sirtuin and clock gene activity, NAD⁺ contributes to circadian rhythm balance, promoting better sleep–wake cycles and metabolic synchronization.
• Safety Observations: NAD⁺ and its precursors (such as NMN and NR) have demonstrated excellent tolerability in preclinical and early human studies, with transient flushing or mild gastrointestinal effects being the most common findings in supplementation research.